Today, January 31 (4:40)
liver cancer causes more deaths around the world than any other cancer. According to the Centers for Disease Control and Prevention (CDC) in the United States alone liver cancer is responsible for approximately 28 thousand. deaths annually. The survival rate of 5 years is only 17 percent. The number of people suffering from this cancer has increased over the last few decades, making the search for effective treatments even more urgent.
A team of researchers from the University of Texas Southwestern Medical Center to fight cancer decided to use short nucleic acids called microRNAs (miRNA). While they are a good candidate for use in anti-cancer therapy, their use has so far been impossible. Failed to create an effective transport miRNA molecules into tumor cells did not exhibit the same toxicity.
US scientists have synthesized a 1500 different types of nanoparticles, which are characterized by different physical and chemical properties. Finally, dendrimers could be identified which are able to transport miRNAs late forms of cancer with a low level of toxicity.
Dendrimers are organic chemical compounds with a regular branched structure forming fraktalopodobne structure. They have a number of unique properties useful in many applications, including as liquid diffraction gratings, the components of diagnostic tests whether these transporters of drugs.
The new media have successfully passed laboratory tests on mice with an aggressive form of liver cancer, inhibiting tumor growth and significantly prolonging survival of patients. The next step is clinical trials to verify whether this method will be effective in humans.
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